一、个人简介
姓名：姚后宗
职称：副教授
学位：博士
硕导/博导：生物与医药专业硕导
籍贯：江西省乐安县
二、学习经历
2017.06 – 2021.10，香港城市大学，化学，博士
2012.09 – 2015.06，苏州大学，药物化学，硕士
2008.09 – 2012.06，苏州大学，药学，学士
三、工作经历
2023.12 – 至今 江西师范大学，健康学院，副教授
2022.04 – 2023.12，江西师范大学，健康学院，讲师
2015.12 – 2017.05，香港浸会大学，中医药学院，（高级）研究助理
四、研究兴趣
1.新型RIPK1激酶抑制剂的设计、合成及抗炎活性评价
2.天然产物及其内生真菌中小分子先导化合物的发现与结构优化
3.四价铂类抗癌前药的合成、生物活性与机理研究
五、主持的科研项目
江西省高层次和急需紧缺海外人才引进计划（20223BCJ25009），30万，在研
江西省自然科学基金青年基金项目（20232BAB216132） 10万，在研
江西省教育厅科学技术研究项目重点项目（GJJ2200308），5万，在研
江西师范大学高层次人才引进优秀海归启动经费（12021881），50万，在研
六、代表性论文、论著和专利
1. Jingjie Fang,†Houzong Yao,† Chunlin Zhuang,* Fen-Er Chen*. Insight from linker investigations: Discovery of a novel phenylbenzothiazole necroptosis inhibitor targeting receptor-interacting protein kinase 1 (RIPK1) from a phenoxybenzothiazole compound with dual RIPK1/3 targeting activity. J. Med. Chem.2023, 66, 15288-15308.
2. Qingting Zeng, Hao Cui, Houzong Yao,* Tao Yuan.* Five Sesquiterpenes from Paraconiothyrium sp. and Their Anti-inflammatory Activity.Chem. Biodiversity2023, e202300477.
3. Zhiqin Deng,†Houzong Yao,† Zhigang Wang, Guangyu Zhu. Platinum anticancer drugs: Targeting and delivery. In Bioinorganic Chemistry and Homogeneous Biomimetic Inorganic Catalysis; Pecoraro, V. L.; Guo, Z.; in Comprehensive Inorganic Chemistry III; Reedijk, J., Poeppelmeier, K. R., Eds.; Vol. 2, pp 808–846. Oxford: Elsevier. 2023.
4. Houzong Yao, Guangyu Zhu. Blood Components as Carriers for Small-Molecule Platinum Anticancer Drugs. ChemMedChem. 2022, e202200482.
5. Houzong Yao,† Zhigang Wang,† Na Wang, Zhiqin Deng, Gongyuan Liu, Jianghong Zhou, Shu Chen, Jiahai Shi, Guangyu Zhu.Enhancing circulation and tumor accumulation of carboplatin via an erythrocyte-anchored prodrug strategy.Angew. Chem. Int. Ed.2022, e202203838.
6. Houzong Yao, Guangyu Zhu. A platinum-based fluorescent turn on sensor to decipher the reduction of platinum(IV) prodrugs.Dalton Trans.2022, 51, 5394−5398.
7. Houzong Yao, Yuliana F. Gunawan, Gongyuan Liu, Man-Kit Tse, Guangyu Zhu.Optimization of axial ligands to promote the photoactivation of BODIPY-conjugated platinum (IV) anticancer prodrugs.Dalton Trans.2021, 50, 13737−13747.
8. Houzong Yao, Shu Chen, Zhiqin Deng, Man-Kit Tse, Yudai Matsuda, Guangyu Zhu.BODI-Pt, a green-light-activatable and carboplatin-based platinum (IV) anticancer prodrug with enhanced activation and cytotoxicity.Inorg. Chem.2020, 59, 11823−11833.
9. Houzong Yao, Zoufeng Xu, Cai Li, Man-Kit Tse, Zixuan Tong, Guangyu Zhu.Synthesis and cytotoxic study of a platinum (IV) anticancer prodrug with selectivity toward luteinizing hormone-releasing hormone (LHRH) receptor-positive cancer cells.Inorg. Chem.2019, 58, 11076−11084.
10. Shuaijian Ni,†Houzong Yao,† Lili Wang, Jun Lu, Feng Jiang, Aiping Lu, Ge Zhang.Chemical modifications of nucleic acid aptamers for therapeutic purposes.Int. J. Mol. Sci. 2017, 18, 1683.
11. Houzong Yao, Feng Jiang, Aiping Lu, Ge Zhang.Methods to design and synthesize antibody-drug conjugates (ADCs).Int. J. Mol. Sci. 2016, 17, 194.
12. Houzong Yao, Fengyou Liu, Jinglei Chen, Yan Li, Jinhao Cui, Chunhua Qiao. Antischistosomal activity of N,N'-arylurea analogs against Schistosoma japonicum.Bioorg. Med. Chem. Lett.2016, 26, 1386−1390.
13. 姚后宗，尹伟，陈晶磊，乔春华.一种氟代丁酸腺苷衍生物的合成.有机化学. 2014, 34, 1222−1226.
七、联系方式
微信：yhz54242056
邮箱：yaohz@jxnu.edu.cn
欢迎化学（有机化学、无机化学）及药学（药物化学、药理学）背景本科生报考本人研究生。